Renee C.B. Manworren, PhD

Pain and Palliative Care Medicine, Connecticut Children’s Medical Center (Affiliate)

Research Overview

Through my early research efforts, I learned that lack of knowledge regarding prescribing and administration of analgesics compounded by fear of adverse events were the primary barriers to effective management of acute post-operative pain in children. I, therefore, educated healthcare providers in knowledge translation to improve pediatric pain management and led local, national and international advocacy efforts.
acute post-surgical pain remains limited.

Motivated by a desire to advance my research program at a research extensive university with a reputation for excellence in clinical translation, I accepted, in 2011, a clinical position as Nurse Scientist in acute pediatric pain management at Connecticut Children’s Medical Center and a joint faculty appointment as Assistant Professor at UConn School of Nursing and School of Medicine. I am a key contributor for creation of our Surgical-Pain Collaborative for Clinical Care and Research. We are studying home opioid use after common pediatric surgical procedures and have identified aberrant use and possible patterns of diversion. We hope to translate this knowledge to identify anticipatory guidance to prevent these patterns and adjust prescribing decisions to limit the opportunities for further diversion after children’s surgeries. The Connecticut Institute for Clinical and Translational Science recently awarded funding to support collaboration between myself and Drs. Ruaño and Seip in genomics aimed at advancing personalized medicine for children at risk for post-operative pain and adverse analgesic effects. As a result of these collaborative efforts by basic and patient-oriented research scientists, biostatisticians, and pediatric specialists in surgery, nursing, pain medicine, and psychology, standardized datais now collected before and after pediatric orthopedic, urologic and general surgeries. Data from this SPC Registry will be used to delineate biopsychosocial risks for post-operative pain, such as patient anticipated pain and functional outcomes, such as those measured by the Child Acute Pain Functional Ability Questionnaire.

With the CICATS funding, the Registry is being expanded to include the collection of significant genetic markers for pain and analgesic metabolism. These may further inform the clinical patterns of opioid use we are observing.


University of Texas at Arlington PhD 2010 Nursing research
Rush University, Chicago MS 1994 Pediatric Advanced Practice Nurse
Loyola University, Chicago, BSN, 1988 Nursing

Recent Publications

Contact Information
Mailing AddressConnecticut Children's Medical Center
Pain and Palliative Care Medicine
282 Washington Street
Hartford, CT 06106