Na Li

Assistant Professor

PhD

Pharmaceutical Sciences


Research Interests

My research interests are centered on oral drug delivery systems with a goal of improving their bioavailability and consistency. I am particularly interested in research topics related to the phase behavior, bioavailability enhancement, and interactions with the human gut microbiome of oral formulations. Past projects included solid-state and solution-state behavior of high energy solids, with respect to drug release from a dosage form and drug absorption in the human body.

Education

PhD, Purdue University, 2014

Recent Publications

Li, N. and Taylor, L. S. (2019) Microstructure formation for improved dissolution performance of lopinavir amorphous solid dispersions. Molecular Pharmaceutics. 16 (4): 1751–1765. http://dx.doi.org/10.1021/acs.molpharmaceut.9b00117

Li, N. and Taylor, L. S. (2018) Tailoring supersaturation from amorphous solid dispersions. Journal of Controlled Release. 279 (10): 114-125.
https://doi.org/10.1016/j.jconrel.2018.04.014

Mosquera-Giraldo, L. I., Li, N., Wilson, V., Nichols, B., Edgar, K., and Taylor, L. S. (2018) Influence of polymer and drug loading on the release profile and membrane transport of telaprevir. Molecular Pharmaceutics. 15 (4): 1700–1713. http://dx.doi.org/10.1021/acs.molpharmaceut.8b00104

Li, N., Gilpin, C. J., and Taylor, L. S. (2017) Understanding the effect of water on the miscibility and microstructure of amorphous solid dispersions – An AFM-LCR and TEM-EDX study. Molecular Pharmaceutics. 14(5): 1691-1705. http://dx.doi.org/10.1021/acs.molpharmaceut.6b01151

Li, N., Mosquera-Giraldo, L. I., Borca, C. H., Ormes, J. D., Lowinger M., Higgins J. D., Slipchenko, L. V., and Taylor, L. S. (2016) A comparison of the crystallization inhibition properties of bile salts. Crystal Growth & Design. 16(12): 7286-7300. http://dx.doi.org/10.1021/acs.cgd.6b01470

Li, N., Ormes, J. D., and Taylor, L. S. (2016) Leaching of lopinavir amorphous solid dispersions in acidic media. Pharmaceutical Research. 33(7): 1723-1735.
http://dx.doi.org/10.1007/s11095-016-1913-5

Li, N. and Taylor, L. S. (2016) Nanoscale infrared, thermal, and mechanical characterization of telaprevir-polymer miscibility in amorphous solid dispersions prepared by solvent evaporation. Molecular Pharmaceutics. 13(3): 1123-1136. http://dx.doi.org/10.1021/acs.molpharmaceut.5b00925

Li, N., Taylor, L. S., Mauer, L. J. (2016) Heat transport model for the deliquescence kinetics of crystalline ingredients and mixtures. Journal of Food Engineering. 169: 298-308. http://dx.doi.org/10.1016/j.jfoodeng.2015.08.013

Lipasek, R. A., Li, N., Taylor, L. S., Mauer, L. J. (2015) Effect of temperature and initial moisture content on the chemical stability and color change of various forms of vitamin C. International Journal of Food Properties. 18(4): 862-879. http://dx.doi.org/10.1080/10942912.2013.805770

Li, N., Taylor, L. S., Mauer, L. J. (2014) The physical and chemical stability of amorphous (-)-epi-gallocatechin gallate: effect of water vapor sorption. Food Research International. 58:112-123. http://dx.doi.org/10.1016/j.foodres.2014.01.043

Lipasek, R. A., Li, N., Schmidt, S. J., Taylor, L. S., Mauer, L. J. (2013) Effect of temperature on the deliquescence properties of food ingredients and blends. Journal of Agricultural and Food Chemistry. 61: 9241-9250. http://dx.doi.org/10.1021/jf402585t

Li, N., Taylor, L. S., Ferruzzi, M. G., Mauer, L. J. (2013) Color and chemical stability of tea polyphenol (−)-epigallocatechin-3-gallate in solution and solid states. Food Research International. 53: 909-921. http://dx.doi.org/10.1016/j.foodres.2012.11.019

Li, N., Taylor, L. S., Ferruzzi, M. G., Mauer, L. J. (2012) Kinetic study of catechin stability: effects of pH, concentration, and temperature. Journal of Agricultural and Food Chemistry. 60: 12531-12539. http://dx.doi.org/10.1021/jf304116s

Li, N., Taylor, L. S. and Mauer, L. J. (2011) Degradation kinetics of catechins in green tea powder: Effects of temperature and relative humidity. Journal of Agricultural and Food Chemistry. 59: 6082-6090. http://dx.doi.org/10.1021/jf200203n

Contact Information
Emaillina@uconn.edu
Phone(860) 486-2493
Mailing Address69 North Eagleville Road, Unit 3092 Storrs, Connecticut 06269 United States
CampusStorrs