Lila Worden, MD

Assistant Professor

Pediatrics / CCMC, UConn Health


Research Overview

I am interested in pediatric epilepsy and dietary therapies for epilepsy (ketogenic diet, modified ketogenic diet). I plan to use my time to examine use of ketogenic diets in juvenile myoclonic epilepsy populations, and would like to explore using text or phone-based interventions to improve quality of life in epilepsy relating to dietary adherence, anti-seizure medication adherence, and screening for co-morbid conditions in epilepsy such as anxiety and depression. I have experience in epilepsy research in EEG-based neonatal seizure predictors, use of outpatient therapies for non-convulsive status epilepticus in genetic epilepsy, and evaluation of safety and tolerability of urgent ketogenic diet initiations in an ICU setting.

Education

MD Johns Hopkins University School of Medicine 2013

Recent/Selected Publications

Tablet-based electroencephalography diagnostics for patients with epilepsy in the West African Republic of Guinea.
Sokolov E, Abdoul Bachir DH, Sakadi F, Williams J, Vogel AC, Schaekermann M, Tassiou N, Bah AK, Khatri V, Hotan GC, Ayub N, Leung E, Fantaneanu TA, Patel A, Vyas M, Milligan T, Villamar MF, Hoch D, Purves S, Esmaeili B, Stanley M, Lehn-Schioler T, Tellez-Zenteno J, Gonzalez-Giraldo E, Tolokh I, Heidarian L, Worden L, Jadeja N, Fridinger S, Lee L, Law E, Fodé Abass C, Mateen FJ.
Eur J Neurol. 2020 Aug;27(8):1570-1577. doi: 10.1111/ene.14291. Epub 2020 May 30.
PMID: 32359218

Ketogenic diet treatment of children in the intensive care unit: Safety, tolerability, and effectiveness.
Worden LT, Abend NS, Bergqvist AGC.
Seizure. 2020 Jul 13;80:242-248. doi: 10.1016/j.seizure.2020.07.003. Online ahead of print.
PMID: 32674044

Comprehensive Migraine Initiative in the Pediatric Emergency Department Improves Treatment Outcomes.
Skora CE, Worden LT, Oakley CB.
J Child Neurol. 2020 Mar;35(3):235-241. doi: 10.1177/0883073819889711. Epub 2019 Dec 5.
PMID: 31805806

The probability of seizures during continuous EEG monitoring in high-risk neonates.
Worden LT, Chinappen DM, Stoyell SM, Gold J, Paixao L, Krishnamoorthy K, Kramer MA, Westover MB, Chu CJ.
Epilepsia. 2019 Dec;60(12):2508-2518. doi: 10.1111/epi.16387. Epub 2019 Nov 19.
PMID: 31745988

Diazepam for outpatient treatment of nonconvulsive status epilepticus in pediatric patients with Angelman syndrome.
Worden L, Grocott O, Tourjee A, Chan F, Thibert R.
Epilepsy Behav. 2018 May;82:74-80. doi: 10.1016/j.yebeh.2018.02.027. Epub 2018 Mar 27.
PMID: 29597185

Acceptability of Standardized EEG Reporting in an Electronic Health Record.
Witzman S, Massey SL, Kessler S, Gonzalez-Giraldo E, Fridinger SE, Worden L, Lewin N, Dlugos D, Melamed S, Fitzgerald M, Fung FW, Ferruzi M, McNamee N, LaFalce D, Donnelly M, Haywood A, Allen-Napoli L, Banwell B, Abend NS.
J Clin Neurophysiol. 2019 Oct 28:10.1097/WNP.0000000000000639. doi: 10.1097/WNP.0000000000000639. Online ahead of print.
PMID: 31688354

Is there an ideal way to discontinue the ketogenic diet?
Worden LT, Turner Z, Pyzik PL, Rubenstein JE, Kossoff EH.
Epilepsy Res. 2011 Aug;95(3):232-6. doi: 10.1016/j.eplepsyres.2011.04.003. Epub 2011 May 4.
PMID: 21536412

Diagnostic evaluation in children with developmental delay: a cautionary tale for genetic testing.
Desale M, Worden LT, Cohen JS, Wilms Floet AM, Hoon AH Jr.
Clin Pediatr (Phila). 2012 Dec;51(12):1208-10. doi: 10.1177/0009922812460916. Epub 2012 Oct 3.
PMID: 23034944

A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cells.
Vazin T, Becker KG, Chen J, Spivak CE, Lupica CR, Zhang Y, Worden L, Freed WJ.
PLoS One. 2009 Aug 12;4(8):e6606. doi: 10.1371/journal.pone.0006606.
PMID: 19672298

Nucleus accumbens adenosine A2A receptors regulate exertion of effort by acting on the ventral striatopallidal pathway.
Mingote S, Font L, Farrar AM, Vontell R, Worden LT, Stopper CM, Port RG, Sink KS, Bunce JG, Chrobak JJ, Salamone JD.
J Neurosci. 2008 Sep 3;28(36):9037-46. doi: 10.1523/JNEUROSCI.1525-08.2008.
PMID: 18768698

Cocaine causes deficits in radial migration and alters the distribution of glutamate and GABA neurons in the developing rat cerebral cortex.
Lee CT, Chen J, Worden LT, Freed WJ.
Synapse. 2011 Jan;65(1):21-34. doi: 10.1002/syn.20814.
PMID: 20506319

Intra-accumbens injections of the adenosine A2A agonist CGS 21680 affect effort-related choice behavior in rats.
Font L, Mingote S, Farrar AM, Pereira M, Worden L, Stopper C, Port RG, Salamone JD.
Psychopharmacology (Berl). 2008 Sep;199(4):515-26. doi: 10.1007/s00213-008-1174-z. Epub 2008 May 20.
PMID: 18491078

The adenosine A2A antagonist MSX-3 reverses the effort-related effects of dopamine blockade: differential interaction with D1 and D2 family antagonists.
Worden LT, Shahriari M, Farrar AM, Sink KS, Hockemeyer J, Müller CE, Salamone JD.
Psychopharmacology (Berl). 2009 Apr;203(3):489-99. doi: 10.1007/s00213-008-1396-0. Epub 2008 Dec 2.
PMID: 19048234

Contact Information
Emaillworden@connecticutchildrens.org
Phone(860) 837-7581
Mailing Address505 Farmington Ave
Suite 200
Farmington, CT 06032