Greg Sartor

Assistant Professor

Pharmaceutical Sciences


Research Interests

The Sartor lab utilizes behavioral, pharmacological, epigenetic, and cell type-specific analyses to investigate the neurobiological mechanisms underlying substance use disorder and other types of mental illness. Our lab is eager to collaborate with researchers at UConn in the fields of neuroscience, epigenetics, cell type-specific methods, bioinformatics, and drug discovery.

Education

Ph.D. Medical University of South Carolina 2011

Recent Publications

W, Wang H, Wei JQ, Sartor GC, Bao M, Pierce C, Wahlestedt C, Dykxhoorn D and Dong C. (2018) Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p—Me1—ROS Pathway. Hypertension, 71(4):752-760. PMC5843539

Volmar CH, Salah-Uddin H, Janczura JK, Halley P, Lambert G, Wodrich A, Manoah S, Patel N, Mehta M, Sartor GC, Mehta N, Miles N, Desse S, Dorcius D, Wahlestedt C. (2017) M344 promotes non-amyloidogenic amyloid precursor protein processing while normalizing Alzheimer’s disease genes and improving memory. Proceedings of the National Academy of Sciences, 114(43): E9135-144. PMC5664514.

Sartor GC, Powell SK, Lin DY, Velmeshev D, Magistri M, Wiedner HJ, Malvezzi AM, Faghihi MA and Wahlestedt C. (2017) Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens. Molecular and Cellular Neuroscience, (85): 183-189. PMC5698162.
2016

Sartor GC, Powell SK, Brothers SP and Wahlestedt C. (2016) Nociceptin receptor activation does not alter acquisition, expression, extinction and reinstatement of conditioned cocaine preference in mice.Brain Research, 1632: 34-21. PMC4733396.

Magistri M, Velmeshev D, Makhmutova M, Patel P, Sartor GC, Volmar CH, Wahlestedt C, Faghihi MA. (2016) The BET-bromodomain inhibitor JQ1 reduces inflammation and tau phosphorylation in the brain of the 3xTg model of Alzheimer’s disease. Current Alzheimer Research, 13(9): 985-95. PMC5026248.

Maruf A, Aziz A, Brothers SP, Sartor G, Heilig M, Wahlestedt C and Thorsell A. (2016) The Nociceptin/Orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models. Psychopharmacology (Berl), 233(19-20): 3553-63. PMC5021736.

Sartor GC, Powell SK, Brothers SP and Wahlestedt C. (2015) Epigenetic readers of lysine acetylation regulate cocaine-induced plasticity. Journal of Neuroscience, 35(45): 15062-72. PMC4642238.

Sartor GC and Aston-Jones G (2014) Post-retrieval extinction attenuates cocaine memories. Neuropsychopharamcology, 39(5):1059-65. PMC3957116.

Mahler SV, Smith RJ, Moorman DE, Sartor GC, Aston-Jones G (2012) Multiple roles for orexin in addiction to drugs of abuse. Progress in Brain Research, 198:79-121. PMC3643893.

Sartor GC, St Laurent G 3rd, Wahlestedt C. (2012) The emerging role of non-coding RNAs in drug addiction. Frontiers in Genetics, 3: 106. PMC3381216. ​

Sartor GC and Aston-Jones G (2012) Regulation of ventral tegmental area by bed nucleus of the stria terminalis is required for expression of cocaine preference. European Journal of Neuroscience. 36: 3549-58. PMC3514627.

Sartor GC and Aston-Jones G (2012) A septal-hypothalamic pathway drives orexin neurons and cocaine preference. Journal of Neuroscience, 32(13):4623-31. PMC3350779.

Greg Sartor
Contact Information
Emailgregory.sartor@uconn.edu
Phone(860) 486-3655