Mu-Ping Nieh, PhD

Associate Professor, Chemical & Bio-molecular Engineering / School of Engineering, Institute of Materials Science (Affiliate)


Research Overview

My research interests mainly focus on designing self-assembled structures of nanomaterials based on molecular architectures for biomedical applications. Self-assembly allows large-scale manufacturing but precise control of size, polydispersity and morphology of the nanomaterials has been major issues in the past. We apply the principle of fundamental physical chemistry to achieve the desired nanostructures and functions. Specifically, we have designed an developed spontaneously forming lipid-based vesicles and nanodiscs as delivery platforms for therapeutics and/or diagnostics. These platforms have shown great potential to enhance cellular internalization of hydrophilic, lipophilic or amphiphilic molecules. As an InChip affiliate, I plan to collaborate with the researchers who are interested in codeveloping useful nanoplatforms to package biomolecules such as DNA, RNA, therapeutics, diagnostics, etc.
Since I have been using scattering techniques (neutron, X-ray and light) to probe nanostructures of materials, another potential collaboration area would be providing help for other researchers to characterize the nanostructures of biomaterials. These scattering techniques can reveal not only global (instead of local) nanostructures and phase behavior of the studied materials but also certain slow in-situ kinetics, e.g., particle coalescence and molecular exchange, at the time scale of minutes and longer.

Education

Ph.D. (1998) Chemical Engineering/Polymer Science & Engineering, University of Massachusetts, Amherst
B. Sc. (1989) Chemical Engineering, National Taiwan University

Recent Publications

Contact Information
Emailmu-ping.nieh@uconn.edu
Phone860.486.8708
Mailing AddressInstitute of Materials Science
97 N. Eagleville Rd.
Storrs, CT 06269